Get A Preview Of Sinclair Research's Safety Pharmacology Validation Data
In this 10-minute video presentation on demand, Dr. Michael R. Gralinski, CEO of CorDynamics, reviews the results of 3 safety pharmacology validation studies that were conducted in 2020 in Sinclair Research's purpose-built telemetry facility to validate GLP Safety Pharmacology service offerings.
Three pharmacological validation studies were conducted in telemetered dogs using well characterized hemodynamic, electrocardiographic, and respiratory positive controls. All three studies demonstrated ability to detect expected effects of positive controls with a high degree of fidelity.
Three pharmacological validation studies were conducted:
Validation Study #1 - Hemodynamics: Verapamil (0, 1.5, 15 mg/kg)
Validation Study #2 - Respiratory: Doxapram (0, 1.5, 4 mg/kg)
Validation Study #3 - Electrocardiography and arrhythmias: Dofetilide (0, 0.1, 0.3 mg/kg)
Watch The Video Presentation on demand